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Press Releases

Check-Cap Enrolls First Patient in Clinical Trial to Support CE Mark of Its C-Scan® Colorectal Cancer Screening System
Preparation-free, capsule-based technology has potential to improve colorectal cancer screening rates

    
    Check-Cap Ltd. (the "Company" or "Check-Cap") (NASDAQ: CHEK, CHEKW), a clinical stage
medical diagnostics company developing a capsule-based system for preparation-free,
colorectal cancer (CRC) screening, today announced the enrollment of the first patient in
its multi-center study of the C-Scan(R) system in support of its CE Mark submission.

    C-Scan employs proprietary, ultra-low-dose X-ray technology in an ingestible capsule
to create a 3D map of the inner colon to detect polyps, which may be, or may become,
cancerous. Unlike existing imaging modalities, Check-Cap's approach does not require bowel
preparation, which is a significant obstacle to screening. Designed to improve the patient
experience and maximize the number of people who complete screening, C-Scan works in
concert with the natural functioning of the colon, and does not require sedation or
changes to diet and normal daily activities.

    "Completing the optimization of our system and initiating the trial to support CE
Marking is a very positive step forward in the development of a more patient-friendly
alternative to today's invasive and preparation-intensive approaches to CRC prevention,"
said Bill Densel, CEO of Check-Cap. "We believe that 2017 promises to be a pivotal year
for Check-Cap. In addition to submitting for a CE Mark, we plan to initiate a pilot trial
in the U.S. in the second half of this year. Recently, we held our first pre-submission
meeting with the U.S. Food and Drug Administration and were encouraged by our initial
discussions with the Agency."

    The current multi-center, prospective trial, designed to demonstrate the safety and
clinical performance of C-Scan, will evaluate polyp detection as compared to colonoscopy.
Check-Cap expects to submit for a CE Mark in the first half of 2017.

    Mr. Densel added, "A robust body of data has shown that screening can reduce mortality
by detecting precancerous polyps and early stage CRC. However, individuals have clear
preferences, determined by test characteristics, which influence the uptake of existing
screening options. We are dedicated to achieving accurate polyp detection, comfort and
convenience in a single test, and are committed to developing C-Scan as an option to
increase screening rates."

    About Check-Cap 

    Check-Cap is a clinical-stage medical diagnostics company developing C-Scan(R), the
first capsule-based system for preparation-free, colorectal cancer screening.

    Utilizing innovative ultra-low dose X-ray and wireless communication technologies, the
capsule generates information on the contours of the inside of the colon as it passes
naturally.  This information is used to create a 3D map of the colon, which allows
physicians to look for polyps and other abnormalities. Designed to improve the patient
experience and increase the willingness of individuals to participate in recommended
colorectal cancer screening, C-Scan removes many frequently-cited barriers, such as
laxative bowel preparation, invasiveness and sedation The Check-Cap system is currently
not cleared for marketing in any jurisdiction.

    Legal Notice Regarding Forward-Looking Statements 

    This press release contains "forward-looking statements." Words such as "may," "should,"
"could," "would," "predicts," "potential," "continue," "expects," "anticipates," "future,
" "intends," "plans," "believes," "estimates," and similar expressions, as well as
statements in future tense, often signify forward-looking statements. Forward-looking
statements should not be read as a guarantee of future performance or results and may not
be accurate indications of when such performance or results will be achieved.
Forward-looking statements are based on information that the Company has when those
statements are made or management's good faith belief as of that time with respect to
future events, and are subject to risks and uncertainties that could cause actual
performance or results to differ materially from those expressed in or suggested by the
forward-looking statements. For a discussion of these and other risks that could cause
such differences and that may affect the realization of forward-looking statements, please
refer to the "Special Note On Forward-looking Statements" and "Risk Factors" in the
Company's Annual Report on Form 20-F and other filings with the Securities and Exchange
Commission (SEC). Investors and security holders are urged to read these documents free of
charge on the SEC's web site at http://www.sec.gov . The Company assumes no obligation to
publicly update or revise its forward-looking statements as a result of new information,
future events or otherwise. 

For further information: CONTACT: Investors David Carey Lazar Partners Ltd. +1-212-867-1768 dcarey@lazarpartners.com Vivian Cervantes PCG Advisory +1-212-554-5482 vivian@pcgadvisory.com Media Erich Sandoval or Rob Sawyer Lazar Partners Ltd. +1-213-908-6226 or +1-212-843-0209 esandoval@lazarpartners.com rsawyer@lazarpartners.com